为了帮助好友文斯(斯蒂芬·格拉汉姆 Stephen Graham 饰)度过伤心的离婚,一群好友尼尔(丹尼·戴尔 Danny Dyer 饰)、科勒雷(比利·穆瑞 Billy Murray 饰)、米奇(洛尔·克拉克 Noel Clarke 饰)、马特(李·恩格里比 Lee Ingleby 饰)等人带着他前往一偏僻小镇度假。本以为去的是人间天堂,结果他们却发现这里根本就是地狱,因为这里的女人都染上了怪病,会像僵尸一样袭击、吃掉所有男人。尽管这些男人平时都是唯唯诺诺的“妻管严”,但是面对女僵尸他们绝不手软,于是一场好好的度假彻底沦为了爷们儿大战女僵尸的战争。
Jack is caught with the wife of his employer, a Vegas thug. The thug sends goons after Jack, who convinces his best friend, Pilot, to flee with him. Pilot insists that they head for Seattle, but doesn't tell Jack why. The goons learn from Pilot's drug source where the youths are headed, and they follow, hell bent on breaking Jack's feet. On the road, Jack and Pilot give a ride to Cassie, a distressed young woman. She and Jack hit it off. They pick up an aging stoner headed to Seattle for Kurt Cobain's memorial, and they help a circus sideshow family. Why is Pilot so set on Seattle, will the goons catch Jack, and is there any way the friends' competing needs can be resolved?